High-Throughput Electrospinning System| Latest research progress on antibacterialproperties of chitosan-based nanofibers 2025-06-12
Chitosan is widely sourced, offering excellent biocompatibility, biodegradability, non-toxicity, antibacterial properties, high safety, and environmental friendliness. Due to the presence of amino groups in chitosan, it readily protonates into a polyelectrolyte under acidic conditions. During electrospinning, this increases repulsion between polymer ionic groups, leading to bead formation and difficulty in jetting from the needle, resulting in poor spinnability of chitosan-containing spinning solutions. To address this, polyvinyl alcohol (PVA), polyethylene oxide (PEO), or other spinning aids are often added to interact with chitosan via hydrogen bonds, reducing electrostatic repulsion and surface tension to improve spinnability. Concurrently, incorporating various antibacterial agents not only resolves spinning challenges but also enhances the nanofibers' antibacterial performance.
