Electrospinning Machine| Customizable Silk Fibroin-Based Hydrogel Fibrous Scaffold for On-Demand Multifaceted Tissue Repair

Challenge: Hydrogel scaffolds are attractive tools for tissue repair. However, targeted tissue repair requires specific shape and biofunctional design, and most natural protein-based hydrogel scaffolds are mainly limited to specific tissue repair applications.

Approach: Professor Fan Yubo, Professor Liu Haifeng, and others from Beihang University developed a dynamically functionalized matrix by combining methacrylated silk fibroin (SFMA) with acrylated bisphosphonate (AcBP), which enables (1) customizable shape control through an adjustable electrospinning collector, and (2) on-demand biofunctional customization through metal ion chelation.

Innovation 1: The platform's scenario-specific therapeutic effects: (i) Mg2+-functionalized membrane (S-LB-Mg) coordinates angiogenesis-osteogenesis coupling in critical-size cranial defects, (ii) Ag+-integrated filler (S-LB-Ag) achieves bacterial eradication through non-antibiotic mechanisms and accelerates infected wound healing, and (iii) Zn2+-loaded conduit (S-LB-Zn) drives macrophage M2 polarization to enhance peripheral nerve regeneration.

Innovation 2: This naturally derived protein-based platform overcomes the potential side effects associated with clinical bioactive factor/antibiotic composite scaffolds, providing a simple and customizable solution for the repair and regeneration of multiple tissues in a cost-effective manner.

DOI: https://doi.org/10.1021/acsnano.5c03283