Electrospinning Machine | Spatiotemporal Delivery of Required Facilitators for Microenvironment Remodeling Propels Neural Regeneration after Spinal Cord Injury

Challenge: The complex pathological response and multiple components within the injury make spinal cord injury repair challenging. 

Method: Professor He Liumin from The Third Affiliated Hospital of Sun Yat-sen University collaborated with Professor Xue Jiajia from Beijing University of Chemical Technology, using polycaprolactone (PCL) nanofiber membranes to wrap sandwich-like hydrogels, preparing a multifunctional hybrid nerve repair conduit. 

Innovation 1: This sandwich structure consists of hyaluronic acid-graft-dopamine (HRR) hydrogel, which loads epidermal growth factor (EGF), neurotrophin-3 (NT3), and glial cell-derived neurotrophic factor (GDNF), with gelatin methacryloyl (GelMA) hydrogel containing catalase at both ends. 

Innovation 2: This hybrid conduit can spatiotemporally release multiple bioactive factors, precisely targeting key pathological cascades after spinal cord injury. This method reduces oxidative stress, promotes neuronal survival at the lesion edge, facilitates the transmission of ascending and descending axons, and enhances signal transmission across the lesion. 

Innovation 3: The restored serotonergic signaling enhances motor neuron excitability, promotes functional recovery, while the reconstruction of bladder reflexes improves urinary control. 

https://doi.org/10.1002/adma.202503479