Electrospinning Machine | Sprayable Photothermal Fiber-Embedded Hydrogels to Engineer Microenvironment for Infected Wound Healing

Challenge: The treatment of infectious irregular wounds remains one of the most significant challenges in clinical practice. Sprayable hydrogels have attracted widespread attention due to their excellent adaptation to irregular wounds. However, developing hydrogels with programmable antibacterial, anti-inflammatory, and regenerative properties to match the healing process still faces severe challenges.
Method: Researcher Wang Xianfeng and Researcher Li Xiaoran from Professor Ding Bin's team at Donghua University developed a sprayable and photothermal fiber-embedded hydrogel dressing by incorporating gold nanorods (AuNRs) and anti-inflammatory drug diclofenac sodium (DS)-loaded poly(lactic-co-glycolic acid) (PLGA) electrospun fibers into a matrix cell-derived factor 1α (SDF-1α) immobilized gelatin methacryloyl hydrogel.
Innovation 1: Benefiting from the photothermal conversion特性 of AuNRs and the suitable glass transition temperature of PLGA short fibers, the hydrogel can not only achieve photothermal bacteriostasis but also enable on-demand light-triggered release of DS to produce anti-inflammatory activity.
Innovation 2: In vivo experiments showed accelerated healing of infected wounds. RNA sequencing analysis revealed that the hydrogel can suppress pathways related to the inflammatory response.
https://doi.org/10.1002/adfm.202501242