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Challenge: In the field of tissue engineering, guided bone regeneration (GBR) technology faces multidimensional challenges. Current commercial collagen membranes have limited mechanical properties and lack antibacterial capabilities, making them prone to postoperative rupture or infection. While titanium meshes enhance mechanical strength, they are non-degradable and carry risks of secondary surgery. Other synthetic membranes also fail to simultaneously address these conflicting demands, making this a core challenge in bone regeneration.
Method: Professor Wang Zuolin from Tongji University, Academician Yu Shuhong from the University of Science and Technology of China, and Special Associate Researcher Chen Siming collaborated to develop a multifunctional biomimetic Janus nanocomposite membrane (d-BLG), inspired by natural nacre (discontinuous "brick-mortar" structure) and Bouligand (helical fiber arrangement), through structural design and component regulation.
Innovation 1: The membrane integrates "spear" (active offense) and "shield" (passive defense). As a "spear," its high toughness actively adapts to bone ridges, captures water molecules to drive osteogenic expression, and kills bacteria. As a "shield," its high strength passively resists external forces, maintaining structural integrity as a cell proliferation barrier.
Innovation 2: The membrane is prepared using a mild and efficient liquid-phase sliding shear method, offering scalability potential and providing new insights for biomaterial design.
