Electrospun Non‐Woven Nanofibrous Hybrid Mats Based on Chitosan and PLA for Wound‐Dressing Applications

Continuous defect‐free nanofibers containing chitosan (Ch) or quaternized chitosan (QCh) were successfully prepared by one‐step electrospinning of Ch or QCh solutions mixed with poly[(L‐lactide)‐co‐(d,l‐lactide)] in common solvent. XPS revealed the surface chemical composition of the bicomponent electrospun mats. Crosslinked Ch‐ and QCh‐containing nanofibers exhibited higher kill rates against bacteria S. aureus and E. coli than the corresponding solvent‐cast films. SEM observations showed that hybrid mats were very effective in suppressing the adhesion of pathogenic bacteria S. aureus. The hybrid nanofibers are promising for wound‐healing applications.

Published: 2008

Journal :MACROMOL BIOSCI

Impact Factor：3.42

Paper link：https://onlinelibrary.wiley.com/doi/abs/10.1002/mabi.200800189