High-Throughput Electrospinning System| A Functional 3D Biomimetic Osteon Accelerates BoneRegeneration

Prof. Bin Li's Team at Soochow University: Functional 3D Biomimetic Bone Accelerates Bone Regeneration

Challenge: The unique structure and composition of Haversian canals in bone cells play a crucial role in maintaining nutrient supply to individual bone cells. Consequently, the inherent advantages of bone tissue in promoting bone repair have attracted increasing attention. However, most existing designs only mimic partial aspects of bone structure and fail to fully replicate its architecture and function.

Method: A collaborative team led by Prof. Bin Li and Prof. Fengxuan Han (Soochow University) with Prof. Jinbo Liu (Third Affiliated Hospital of Soochow University) utilized electrospinning technology to prepare nanofiber scaffolds mimicking bone lamellae of osteons, employed microfluidics to create biomimetic vessels simulating Haversian canals, and introduced rat umbilical vein endothelial cells to develop a functional 3D biomimetic bone for enhanced bone regeneration.

Innovation 1: The biomimetic vessels implanted with rat umbilical vein endothelial cells secreted bone morphogenetic proteins to stimulate osteogenesis and released platelet-derived growth factors to promote angiogenesis, further supporting the osteogenic process.

Innovation 2: The nanofibers composed of type I collagen and nano-hydroxyapatite released calcium ions, which promoted the recruitment of bone marrow mesenchymal stem cells, enhanced their adhesion to the fibers, and facilitated osteogenic differentiation.