Large-Scale Nanofiber Manufacturing| Electronic vascular conduit for in situ identification ofhemadostenosisandthrombosis insmallanimals andnonhuman primates

Academician Wang Zhonglin and Li Linlin et al. from Beijing Institute of Nanoenergy and Nanosystems, Nat. Commun. (IF 14.7): A Self-Monitoring, Power-Generating Artificial Electronic Blood Vessel

Challenge: Coronary artery disease or peripheral artery disease can be treated with bypass surgery and arterial vascular transplantation, but there are many post-transplant challenges, particularly delayed endothelialization, intimal hyperplasia, high risk of thrombosis and restenosis, as well as difficulty in timely detection of these subtle pathological changes.

Approach: Researcher Li Linlin from Beijing Institute of Nanoenergy and Nanosystems, Academician Wang Zhonglin, and Chief Physician Zou Duohong from Shanghai Jiao Tong University's Ninth People's Hospital fabricated a bionic bilayer artificial blood vessel through electrospinning, integrating flexible electronic devices into the bionic vascular graft for in situ, real-time and long-term monitoring of blood cell stenosis, thrombosis, and postoperative vascular repair.

Innovation 1: After bypass surgery, the integrated bioelectronic sensor based on triboelectric effect can monitor blood flow in the vascular graft and identify lesions in real time for up to three months.

Innovation 2: In male non-human primate models, the electronic vascular catheter integrated with a wireless signal transmission module can wirelessly monitor hemodynamics in real time and promptly identify thrombosis.

https://www.nature.com/articles/s41467-025-58056-2