Large-Scale Nanofiber Manufacturing| Engineeringspatially-confined conduits to tune nerveself-organization and allodynic responses via YAP.mediated mechanotransduction

Prof. Xiumei Wang from Tsinghua University (Nat. Commun., IF 14.7): Spatially confined conduits modulate neural self-organization and hyperalgesia responses.

Challenge: Peripheral nerve truncation often leads to neuroma formation and chronic pain, with limited efficacy from conventional treatments. While nerve conduits exist, standard designs fail to manage orderly nerve termination.

Approach: Prof. Xiumei Wang's team developed tapered spatially confined conduits (CC) by combining molecular self-assembly, electrospinning, and mechanical compression to create PCL@MC layered structures.

Innovation 1: The design enables axons to autonomously decelerate growth within progressively narrowing spaces while suppressing neuroinflammation via YAP-mediated mechanotransduction activation.

Innovation 2: Decelerated axons demonstrate aligned regeneration and remyelination, preventing pathological self-organization. This CC strategy significantly reduces hyperalgesia, offering a promising clinical solution for amputated neuroma and neuropathic pain.