Large-Scale Nanofiber Manufacturing| Photo-Responsive HzS Composite System Regulates the NerveRegeneration Microenvironment Through Multiple Pathways

Prof. Dai Honglian et al. from Wuhan University of Technology Adv. Mater.: Photo-responsive H2S Composite System Regulates Nerve Regeneration Microenvironment Through Multiple Pathways

Challenge: Drug-delivering nerve conduits play a role in repairing the regeneration microenvironment. However, traditional drugs often cannot cross the blood-nerve barrier and lack multifunctionality, limiting the therapeutic effectiveness of conduits.

Approach: Prof. Dai Honglian from Wuhan University of Technology and Prof. Yu Aixi from Wuhan University developed a photo-responsive hydrogen sulfide (H2S) composite nerve conduit for artificial control of H2S release.

Innovation 1: A novel zinc-citrate metal-organic framework structure was utilized to enhance drug loading capacity, achieving combined regulation of the nerve regeneration microenvironment by H2S and Zn2+.

Innovation 2: H2S and Zn2+ can modulate inflammatory responses and oxidative stress, promote mitochondrial function recovery and angiogenesis. Additionally, the aligned structure can facilitate cell adhesion and guide directional cell migration.