Large-Scale Nanofiber Manufacturing| Tissue Mimetic Membranes for Healing Augmentation ofTendon-Bone Interface in Rotator Cuff Repair

Professor Wei Tao et al. from The Chinese University of Hong Kong: Tissue-Mimicking Membrane for Healing Enhancement at Tendon-Bone Interface in Rotator Cuff Repair

Challenge: Rotator cuff injuries are among the most common musculoskeletal disorders, imposing significant socioeconomic burdens. These injuries typically occur at the tendon-bone interface, causing severe pain and limiting daily activities. Advanced tissue engineering strategies are urgently needed for functional fibrocartilaginous interface reconstruction.

Approach: Professor Wei Tao, Professor Xu Jiankun, and Professor Qin Ling from The Chinese University of Hong Kong collaboratively developed an asymmetric biointerface membrane that mimics tendon-bone interface heterogeneity while simultaneously releasing dual osteogenic/chondrogenic bioinductive signals, successfully guiding interface tissue regeneration and restoring shoulder joint physiological function.

Innovation 1: The membrane consists of a microporous layer containing nGel-KGN and a mineralized core-shell nanofiber layer loaded with St., which mimics interface heterogeneity and exhibits dual-lineage bioinductive effects.

Innovation 2: In a rat rotator cuff injury model, the tissue-mimicking membrane significantly improved tendon-bone interface regeneration, with the 500C/nG-ES/St membrane (containing 4% St. and 5% nGel-KGN, ~45.7 μm microporous layer) demonstrating optimal regenerative performance.