The use of electrospun curcumin-loaded poly(L-lactic acid) fiber mats as wound dressing materials

Electrospun poly(l-lactic acid) (PLLA) fiber mats containing curcumin were prepared by electrospinning. Varying amounts of as-loaded curcumin at 0.2, 0.5, and 1.0% w/w (based on the weight of PLLA) were added in the PLLA solution. Results showed that the obtained fibers were smooth with no surface aggregates, indicating complete incorporation of curcumin. Average diameter of the fibers ranged between ~333 and ~386 nm. Water retention and weight loss of neat and curcumin-loaded PLLA fiber mats in phosphate buffer solution containing Tween 80 and methanol were not significantly different with increasing submersion time. Released amount of curcumin from curcumin-loaded PLLA fiber mats increased with higher loadings of curcumin. Antioxidant activity of the as-released curcumin from the fiber mats ranged between ~18% and ~53%. The materials were non-toxic to human adult dermal fibroblast (HDFa) cells and supported cell attachment and proliferation. These materials showed potential for wound dressing applications.

Published：2021

Journal：Journal of Drug Delivery Science and Technology

Impact Factor：2.734

Paper link：https://www.sciencedirect.com/science/article/abs/pii/S1773224718315922