Electrospinning Machine| Stretchable and Microneedle-Integrated Electronic Patcheswith Actively Controlled Chemothermal Therapy for CancerTreatment

Challenge: Stretchable electronics offer a promising platform for next-generation biomedical devices. However, a major obstacle to their therapeutic efficacy lies in the lack of effective transdermal drug delivery methods.

Approach: Professors Desheng Kong, Xinghai Ning, and Xiaoliang Wang from Nanjing University collaborated to develop an integrated stretchable electronic patch with microneedles. It conforms tightly to epidermal tumor sites and enables wireless smartphone-controlled combination therapy of electrothermal and chemotherapy, effectively preventing tumor recurrence.

Innovation 1: Phase-change materials were used to load and encapsulate the anticancer drug DOX into microcarriers. A stretchable thermosensitive composite fiber fabric was prepared via ultrasonic spraying and electrospinning, exhibiting excellent stretchability and "thermal activation" at 40.8°C.

Innovation 2: Porous microneedles were fabricated on Janus textile using 3D printing and phase separation techniques. The microneedles adhere firmly to the fabric, maintaining structural integrity even under bending, stretching, and twisting, while enabling skin penetration.

Innovation 3: The microneedle-integrated patch was combined with flexible integrated circuits and batteries to design a wearable system for remote smartphone-controlled therapy. The integrated system demonstrated high efficacy and minimal side effects in combined thermo-chemotherapy for melanoma.

https://doi.org/10.1002/adfm.202505261