High-Throughput Electrospinning System| A Janus nanofibrous scaffold integrated withexercise-driven electrical stimulation andnanotopological effect enabling thepromotion of tendon-to-bone healing

Nano Today (IF 17.4): A Janus Nanofiber Scaffold for Promoting Tendon-to-Bone Healing

Challenge: Rotator cuff tears pose global challenges, as current single-suture or synthetic scaffolds fail to achieve true healing of complex tendon-bone interfaces.

Approach: Academician Zhu Meifang's team (Donghua University) developed a Janus nanofiber scaffold with piezoelectric properties and biomimetic collagen alignment via electrospinning PLLA/ZnO and PLLA/BTO bilayers, controlling fiber alignment through rotational speed.

Innovation 1: Biomimetic fiber alignment provides exceptional tensile/suture retention strength, meeting mechanical demands. ZnO/BTO nanoparticles induce piezoelectricity to respectively promote tenogenic and osteogenic differentiation.

Innovation 2: PLLA's slow degradation and piezoelectricity enable motion-driven electrical stimulation, enhancing healing in rat rotator cuff models.