High-Throughput Electrospinning System| Nanofibrous Guidance Conduits with Multiple Gradient Cuesfor Spinal Cord Repair

Professor Lu Yunfeng & Professor Xue Jiajia from Beijing University of Chemical Technology: Novel Nanofiber Conduit for Spinal Cord Repair

Challenge: Spinal cord injury (SCI) is a debilitating condition that causes severe disability and imposes significant economic and social burdens. Current treatment strategies primarily focus on symptom management with limited success in promoting complete neurological recovery.

Approach: Professor Lu Yunfeng and Professor Xue Jiajia from Beijing University of Chemical Technology, in collaboration with Dr. Zhai Jiliang's team from Peking Union Medical College Hospital, developed a nanofiber guidance conduit using electrospinning combined with coaxial electrospray technology. This integrates topological, tactile, and chemotactic cues into a single scaffold.

Innovation 1: The design synergistically promotes cell migration, neural stem cell differentiation into neurons, and axonal extension, significantly improving spinal cord regeneration and functional recovery in rats.

Innovation 2: Single-nucleus RNA sequencing further demonstrated that the guidance conduit inhibits fibroblast proliferation, maintains microglial homeostasis, restores cellular proportions, and promotes regeneration of neuronal axons, dendrites, and synapses.

https://doi.org/10.1002/adma.202503892